PRICE: $17.95 for each 60 capsule bottle (300 mg per capsule) Barlowe's Herbal Elixirs brings you the highest grade and most targeted Nettle Extract which has been specifically designed to increase free testosterone. This is a potent extract which has been standardized to 95% 3,4-divanillyltetrahydrofuran. 300 mg taken once or twice a day is the therapeutic dosage needed to optimally bind SHBG and increase free testosterone. Click on this link: Nettle 95% Extract COA, to see the Certificate of Analysis on this particular batch. Although Nettle (Urtica dioica) has been utilized for hundreds of years to treat a variety of ailments, it is primarily of interest now because it has been discovered that it is able to increase free testosterone in the bloodstream, and 3,4-divanillyltetrahydrofuran is the substance in Nettle which causes this effect. These vegetable-derived capsules (Vegan, Kosher and Halal certified) are filled by hand with a manual encapsulation machine, not with a high speed automatic machine, and thus, only pure, unadulterated Nettle 95% Extract is in the capsules. Capsules produced with high speed machines in herbal remedy and vitamin "factories" contain several other ingredients, including preservatives because so many bottles of product are produced at one time, and lubricants to ensure that the machines will run faster and more efficiently. Check their labels! Also, Barlowe's Herbal Elixirs is one of the very few manufacturers that still pack their products in glass whenever possible, even though glass is more expensive. Barlowe believes that chemicals can leach out of plastic containers and contaminate the contents, and that the use of glass is much better for the environment. For many men, a safe and easy way to increase free testosterone is to prevent it from being converted (aromatized) into estrogen. Too much estrogen plays havoc with a man's sex life by binding to testosterone receptor sites and may contribute to the over-production of sex hormone-binding globulin (SHBG). SHBG binds free testosterone in a way that makes it unavailable to receptor sites in the brain, nerves and genitals. High serum levels of estrogen also trick the brain into thinking that enough testosterone is being produced, thereby slowing the natural production of testosterone. Some studies show that the decline in sexual interest with advancing age is not always due to the amount of testosterone produced, but rather to the increased binding of testosterone to globulin by SHBG. This explains why some older men who are on testosterone replacement therapy do not report a long-term aphrodisiac effect. The artificially administered testosterone becomes bound by SHBG, and is not available to cellular receptor sites where it would normally produce a libido-enhancing effect. Logically, one way of increasing libido in older men would be to block the testosterone-binding effects of SHBG. This would leave more testosterone in its free, sexually activating form. A highly concentrated extract from the Nettle root (especially of 3,4-divanillyltetrahydrofuran) provides a unique mechanism for increasing levels of free testosterone. Recent European research has identified constituents of Nettle root that bind to SHBG in place of testosterone, thus reducing SHBG's binding of free testosterone. Therefore, this product is an excellent herbal extract to take in combination with either Barlowe's Tongkat Ali 100:1 Extract, or his Fenugreek 50% Extract , as both the Tongkat and the Fenugreek dramatically increase level of testosterone, and the 3,4-divanillyltetrahydrofuran keeps the raised testosterone in its free, powerful form. Research: Medical Uses of Nettle Nettle's Use for BPH Interaction of lignans with human sex hormone binding globulin (SHBG).Schottner M, Gansser D, Spiteller G.Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/ )-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).Schottner M, Gansser D, Spiteller G.Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-) secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4 divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-) pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4 divanillyltetrahydrofuran was outstandingly high. These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH). Caution: Barlowe's Nettle Extract uses only the finest quality Nettle 95% Standardized Extract from the most trusted suppliers. This superb, targeted herbal extract is generally safe, but it is potent and should be utilized with care. This product is for dietary use. If side-effects occur, discontinue use immediately! The above statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease. Directions For Use: Take one (300 mg) capsule either once or twice a day. Results and usage amounts may vary based on body type and weight. Nettle Extract 95% 3,4-divanillyltetrahydrofuran PRICE: $17.95 for each 60 capsule bottle (300 mg per capsule)
PRICE: $17.95 for each 60 capsule bottle (300 mg per capsule)
Barlowe's Herbal Elixirs brings you the highest grade and most targeted Nettle Extract which has been specifically designed to increase free testosterone. This is a potent extract which has been standardized to 95% 3,4-divanillyltetrahydrofuran. 300 mg taken once or twice a day is the therapeutic dosage needed to optimally bind SHBG and increase free testosterone. Click on this link: Nettle 95% Extract COA, to see the Certificate of Analysis on this particular batch. Although Nettle (Urtica dioica) has been utilized for hundreds of years to treat a variety of ailments, it is primarily of interest now because it has been discovered that it is able to increase free testosterone in the bloodstream, and 3,4-divanillyltetrahydrofuran is the substance in Nettle which causes this effect. These vegetable-derived capsules (Vegan, Kosher and Halal certified) are filled by hand with a manual encapsulation machine, not with a high speed automatic machine, and thus, only pure, unadulterated Nettle 95% Extract is in the capsules. Capsules produced with high speed machines in herbal remedy and vitamin "factories" contain several other ingredients, including preservatives because so many bottles of product are produced at one time, and lubricants to ensure that the machines will run faster and more efficiently. Check their labels! Also, Barlowe's Herbal Elixirs is one of the very few manufacturers that still pack their products in glass whenever possible, even though glass is more expensive. Barlowe believes that chemicals can leach out of plastic containers and contaminate the contents, and that the use of glass is much better for the environment.
For many men, a safe and easy way to increase free testosterone is to prevent it from being converted (aromatized) into estrogen. Too much estrogen plays havoc with a man's sex life by binding to testosterone receptor sites and may contribute to the over-production of sex hormone-binding globulin (SHBG). SHBG binds free testosterone in a way that makes it unavailable to receptor sites in the brain, nerves and genitals. High serum levels of estrogen also trick the brain into thinking that enough testosterone is being produced, thereby slowing the natural production of testosterone. Some studies show that the decline in sexual interest with advancing age is not always due to the amount of testosterone produced, but rather to the increased binding of testosterone to globulin by SHBG. This explains why some older men who are on testosterone replacement therapy do not report a long-term aphrodisiac effect. The artificially administered testosterone becomes bound by SHBG, and is not available to cellular receptor sites where it would normally produce a libido-enhancing effect.
Logically, one way of increasing libido in older men would be to block the testosterone-binding effects of SHBG. This would leave more testosterone in its free, sexually activating form. A highly concentrated extract from the Nettle root (especially of 3,4-divanillyltetrahydrofuran) provides a unique mechanism for increasing levels of free testosterone. Recent European research has identified constituents of Nettle root that bind to SHBG in place of testosterone, thus reducing SHBG's binding of free testosterone. Therefore, this product is an excellent herbal extract to take in combination with either Barlowe's Tongkat Ali 100:1 Extract, or his Fenugreek 50% Extract , as both the Tongkat and the Fenugreek dramatically increase level of testosterone, and the 3,4-divanillyltetrahydrofuran keeps the raised testosterone in its free, powerful form.
Research:
Medical Uses of Nettle
Nettle's Use for BPH
Interaction of lignans with human sex hormone binding globulin (SHBG).Schottner M, Gansser D, Spiteller G.Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/ )-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).Schottner M, Gansser D, Spiteller G.Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-) secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4 divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-) pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4 divanillyltetrahydrofuran was outstandingly high. These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
Caution:
Barlowe's Nettle Extract uses only the finest quality Nettle 95% Standardized Extract from the most trusted suppliers. This superb, targeted herbal extract is generally safe, but it is potent and should be utilized with care. This product is for dietary use. If side-effects occur, discontinue use immediately! The above statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.
Directions For Use:
Take one (300 mg) capsule either once or twice a day. Results and usage amounts may vary based on body type and weight.
Nettle Extract 95% 3,4-divanillyltetrahydrofuran
