Nettle Root Extract High Potency

NOW 425mg! Barlowe's Herbal Elixirs presents its Nettle High Potency Extract, formulated with men’s wellness in mind. Each capsule contains 425mg of extract standardized to 95% 3,4-divanillyltetrahydrofuran, a natural compound found in Nettle Root and traditionally used in herbal practices that focus on vitality and hormonal support.

This botanical compound is often discussed in relation to its ability to interact with SHBG (Sex Hormone-Binding Globulin), a protein that can affect the availability of certain hormones in the body. By influencing this interaction, it may support overall well-being and male vitality.

Our Nettle High Potency Extract also pairs well with other herbal offerings such as Tongkat Ali, Bulbine Natalensis, or Fenugreek Extracts, which are commonly included in traditional male wellness regimens.

ATTENTION: IF YOU HAVE ANY PRODUCT QUESTIONS, PLEASE CONTACT BARLOWE AT 954-479-4320. WE DO NOT ACCEPT PHONE ORDERS. SORRY.

Testimonials:

I thought you might like to know the results of a recent experiment with your high potency Nettle Root Extract. The background is that in recent years my levels of SHBG (sex hormone binding globulin) have soared considerably beyond the upper limit of the reference range, while my total and free testosterone have declined. After searching the scientific literature, I came across 3,4-DVTHF (3,4-divanillyltetrahydrofuran) as an effective means of lowering SHBG. Further research revealed that some suppliers have been selling products labeled as 3,4-DVTHF actually contained very little. I decided to take a chance on your product because you seem to be a reputable company and your label indicates a high content of purified 3,4-DVTHF per capsule.  After an initial purchase, I bought three bottles of Nettle Root Extract and took 3 capsules twice a day for one month before retesting for SHBG and testosterone. The results showed that my SHBG decreased by 16 nmol/L while my free and total testosterone increased by 1.31 and 11 ng/dL, respectively. While still not at the levels they once were, they nevertheless represent a considerable improvement. Congratulations on selling an honest and effective product! I have told several other people about my results and they are ordering as well. W.S., Arlington, MA (11/26/2018)

Research: 

Nettle's Use for BPH

Interaction of lignans with human sex hormone binding globulin (SHBG).

Schottner M, Gansser D, Spiteller G.

Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.

Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/ )-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.

Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).

Schottner M, Gansser D, Spiteller G.

Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.

Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-) secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4 divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-) pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4 divanillyltetrahydrofuran was outstandingly high. These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).

Caution: This extract is generally safe, but it is potent and should be utilized with care. This product is for dietary use. If side-effects occur, discontinue use immediately! The above statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

Directions For Use: As a dietary supplement, take one capsule twice a day without food. Results and usage amounts may vary based on body type and weight. Keep bottle tightly closed whenever possible as this product is quite hygroscopic and can easily absorb moisture from the air.

Nettle Root Super High Potency Extract        PRICE: $19.95 for each 60 capsule bottle (425 mg per vegi-capsule)